Generalized fatigue after Botulinum neurotoxin A (BoNTA): Research of systemic diffusion with single fiber EMG
نویسندگان
چکیده
منابع مشابه
Effect of botulinum neurotoxin type A (BoNTA) on the morphology and viability of 3T3 murine fibroblasts.
AIM BoNTA is used in the treatment of ophthalmological disorders, muscular hyperactivity and pain. In recent years it has been described that BoNTA reduces cellular viability and induces apoptosis in prostate cells lines. Studies about the effect of BoNTA are no well known. There have been studies about the effect of BoNTA on the expression levels of collagenase in fibroblasts, but not on its m...
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Botulinum neurotoxin (BoNT) is responsible for causing botulism, a potentially fatal disease characterized by paralysis of skeletal muscle. Existing specific treatments include polyclonal antisera derived from immunized humans or horses. Both preparations have similar drawbacks, including limited supply, risk of adverse effects and batch to batch variation. Here, we describe a panel of six high...
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The therapeutic potential of botulinum neurotoxin type A (BoNT/A) has recently been widely recognized. BoNT/A acts to silence synaptic transmission via specific proteolytic cleavage of an essential neuronal protein, SNAP25. The advantages of BoNT/A-mediated synaptic silencing include very long duration, high potency and localized action. However, there is a fear of possible side-effects of BoNT...
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The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric view of these neurotoxins as human botulism-causing a...
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Objective: To assess neuromuscular transmission (NMT) in patients with Meniere's disease (MD), in which the precise etiology is unknown and a channelopathy hypothesis has been proposed Methods: Single fiber electromyography (SFEMG) during voluntary contraction of the extansor digitorum communis muscle, nerve conduction studies of upper and lower extremities and concentric needle electromyograph...
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ژورنال
عنوان ژورنال: Annals of Physical and Rehabilitation Medicine
سال: 2012
ISSN: 1877-0657
DOI: 10.1016/j.rehab.2012.07.827